The first symptom includes weakness or tingling sensations in the legs. But each person may have slightly different symptoms. ![]() These are the most common symptoms of GBS. What are the symptoms of Guillain-Barré syndrome? GBS can occur after a viral infection, surgery, injury, or a reaction to an immunization. The result is an inability to feel heat, pain, and other sensations. When this occurs, the nerves can’t send signals efficiently, the muscles lose their ability to respond to the commands of the brain, and the brain receives fewer sensory signals from the rest of the body. Normally, the cells of the immune system attack only foreign material and invading organisms, but in GBS, the immune system starts to destroy the myelin sheath that surrounds the axons of many nerve cells, and, sometimes, the axons themselves. What is known is that the body's immune system begins to attack the body itself. GBS often develops after a respiratory or gastrointestinal viral infection. It can affect people at any age and both men and women equally. GBS is rare, affecting about 3,000 people in the U.S. It can develop over a few days, or it may take up to several weeks with the greatest weakness occurring within the first couple of weeks after symptoms appear. The onset of GBS can be quite sudden and unexpected and requires immediate hospitalization. It is a neurological disorder in which the body's immune system attacks the peripheral nervous system, the part of the nervous system outside the brain and spinal cord. ![]() Guillain-Barré syndrome (GBS) is also called acute inflammatory demyelinating polyradiculoneuropathy (AIDP).
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